Narrow topic: Symptoms and treatment for aids
Narrower topic: Vaccines, effects on pregnant women, AIDS awareness campaigns
Thesis: For the approximately 3.8 million AIDS patients worldwide, the following issues are of significant concern: AIDS awareness campaigns, effects on pregnant women, and possible vaccines for this virus.
For the above thesis, the following sentence is a possible topic sentence for body paragraph # 1...
Although the AIDS virus has been a known public threat for decades, awareness campaigns continue to be a vital part of the battle against this disease.